Welcome to the MAPD!
This web platform incorporates protein-intrinsic features, MAPD scores (predicted degradability), E2 accessibility of Ub sites in select kinases, ligandability, and disease associations. It enbales rational prioritization of degradable targets for developing degraders by the TPD community.
Cite us!
Wubing Zhang*, Shourya S. Roy Burman*, Jiaye Chen, Katherine A. Donovan, Yang Cao, Boning Zhang, Zexian Zeng, Yi Zhang, Dian Li, Eric S. Fischer#, Collin Tokheim#, X. Shirley Liu#. Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation. bioRxiv 2021 [DOI]
